Invisible Ink: Researchers Use CRISPR to Make See-Through Squid

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This text appeared within the September/October 2021 subject of Uncover. Turn out to be a subscriber for limitless entry to Uncover’s archive.


Can you notice the variations between these child squids? Look carefully: Those with gentle pink eyes and fewer darkish speckles (referred to as chromatophores) acquired a makeover in July 2020 by scientists utilizing the CRISPR-Cas9 geneediting device. A crew of researchers on the Marine Organic Laboratory in Woods Gap, Massachusetts, discovered a solution to make Doryteuthis pealeii hatchlings extra clear by switching off the gene that controls eye and pores and skin cell pigmentation whereas they’re nonetheless embryos. The feat is the primary time researchers have knocked out a gene in cephalopods, a category of invertebrates that features octopus, squid, cuttlefish and nautilus. With future functions in biomedicine, reminiscent of pain-management therapies, the potential to show particular person genes off (and on) might not solely affect our boneless brethren, however people, too.

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